Chemical Exposure Priority Setting Tool™ (CEPST™/ComET©)

CEPST™ has evolved from the Complex Exposure Tool© (ComET©) that The LifeLine Group™ developed for Health Canada.  CEPST™ currently exists as a proof of concept modeling construct.  It demonstrates that for large groups of chemicals with little data and possibly multiple exposure scenarios, users can set priorities for chemicals relative to their exposure potential. The LifeLine Group has developed an approach to do this relative to human health risks. CEPST considers multiple routes of exposure, multiple subpopulations and different possible durations of exposure. Users can change the assumptions in the model and see the impacts.  The full IT implementation of CEPST™ into a software tool is currently under further design and development.

Approaches
Regulatory agencies in Canada, Europe and the USA wish to assess risks to human health when exposed to a multitude of common and relatively unstudied substances.

Canada
One of the first countries to examine the risk from existing chemicals was Canada. The assessment of potential risks to human health posed by existing substances is authorized under the Canadian Environmental Protection Act, 1999 (CEPA 1999). Existing substances include those on the Domestic Substances List (DSL). CEPA 1999 provides the framework for the identification, prioritization and assessment of existing substances and for the control or management of those considered to pose a risk. The LifeLine Group has assisted Health Canada in developing a basic approach known as ComET© that would allow the ranking of any number of these substances. This was presented in an open workshop on November 8, 2004 in Cincinnati, Ohio.

European Union (EU)
Under the REACh (Registration, Evaluation and Assessment of Chemical Hazards) program which is under discussion in Europe, it is anticipated that the EU will require basic data on the physical, toxicological and exposure data on all chemicals used in commerce - sorted by production volume. Also required will be a Human Health and Environmental Risk Assessment using these data. In anticipation of the exposure model development required to accomplish these assessments, the Joint Research Centre of the EU has conducted a series of Workshops in which international experts have gathered to inform the process and the research needed to develop these tools. The LifeLine Group has been involved in the moderation of this workshop series and in the development of these specific tools.

USA
It has recently been reported by the US Government Accounting Office (GAO) that the reauthorization of the USEPA Toxic Substance Control Act (TSCA) could logically flow from the regulatory mandates currently being developed in Canada and the EU.

A demonstration IT implementation of CEPST (previously done for ComET©) is available for download as an ExcelT spreadsheet.       CEPSTbeta.xls

CEPST™ (ComET©) Highlights